软枣猕猴桃的化学成分和药理活性研究进展.PDFVIP

现代药物与临床 Drugs Clinic 第 26 卷 第 3 期 2011 年 5 月 • 203 • 软枣猕猴桃的化学成分和药理活性研究进展 1 1 1, 2* 史彩虹 ，李大伟 ，赵余庆 1. 沈阳药科大学 中药学院，辽宁 沈阳 110016 2. 沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室，辽宁 沈阳 110016 摘 要：软枣猕猴桃为猕猴桃科猕猴桃属多年生落叶藤本植物，在我国东北三省的分布最为广泛。其果实、根、茎叶均可入 药，具有抗肿瘤、抗辐射、提高免疫功能等药理活性。研究表明，软枣猕猴桃全株含有挥发油、三萜、黄酮、多糖等化学成 分。综述了近年来从软枣猕猴桃果实、根、茎叶中分离到的挥发油类、三萜类、黄酮类等化学成分，及其肿瘤抑制、抗辐射、 提高免疫功能、抗衰老、治疗过敏性皮炎、抗哮喘等药理活性，为进一步开发利用该药用植物资源提供理论依据。 关键词：软枣猕猴桃；藤梨根；挥发油类；三萜类；黄酮类；抗肿瘤；抗辐射 中图分类号：R282.71 文献标志码：A 文章编号：1674 - 5515(2011)03 - 0203 - 05 Advances in research on chemical constituents of Actinidia arguta and their pharmacological activities 1 1 1,2 SHI Cai-hong , LI Da-wei , ZHAO Yu-qing 1. College of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 2. China Key Laboratory of Structure-Based Drug Design Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China Abstract: Actinidia arguta belonging to Actinidiaceae, Actinidia Lindl. is perennial defoliation vine plant. It is most widely distributed in the Three Provinces in Northeast of China. All the fruit, root, and stem leaf of A . arguta can be used as medicine, with pharmacological activities of anti-tumour, radioresistance, improving immunity, and so on. The researches indicate that whole plant of A. arguta contains volatile oil, triterpenoids, flavonoid, polysaccharide, etc. In this paper, it provides a summarizing of chemical composition such as volatile oil, triterpenoids, flavonoid extracted from A. arguta for the past few years and pharmacological activities of A. arguta including anti-tumour, radioresistance, improving immunity, anti-aging, curing allergic dermatitis, anti-asthma, etc. The survey offers theoretical basis to the further exploiture and use of A. arguta . Key