单用替吉奥治疗老年晚期胃癌的临床研究.docVIP

精品论文 参考文献 单用替吉奥治疗老年晚期胃癌的临床研究 四川省资中县人民医院 四川资中 641200 【摘 要】目的：探讨单药替吉奥应用在老年晚期胃癌患者中的效果及应用价值。方法：选择我院治疗的老年晚期胃癌患者108例采用随机数字表法分为观察组和对照组，对照组给予奥沙利铂+四氢叶酸+5氟尿嘧啶化疗，观察组给予单药替吉奥治疗，记录两组患者临床治疗效果。结果：观察组总有效率为35.18%，对照组总有效率为37.04%，组间对比差异无统计学意义（P＞0.05）。观察组治疗后卡氏评分（70.18plusmn;6.97）分，疼痛评分（1.54plusmn;0.76）分，观察组不良反应发生率为9.26%，上述指标均优于对照组，组间对比差异有统计学意义（P＜0.05）。结论：单药替吉奥治疗老年晚期胃癌近期疗效可靠，不良反应少，值得在临床上大力推广使用。 【关键词】替吉奥；老年；晚期胃癌 The clinical effect of S-1 on the treatment of Advanced gastric cancer with Elderly patients [Abstract] Objective Discusses the application of s S-1 effect and application value in the elderly patients with advanced gastric cancer.Methods Choose the hospital treatment of 108 cases of elderly patients with advanced gastric cancer by using random Numbers table is divided into observation group and control group，control group given folinic acid（+ + 5 fluorouracil oxaliplatin into chemotherapy，observation group was given for S-1 therapy，records of two groups of patients with clinical therapeutic effect.Results Observation group total effective rate was 35.18%，control group total effective rate was 37.04%，comparing differences between groups have no statistical significance（P gt; 0.05）.Cartesian score group after treatment（70.18 6.97 mm），pain score（1.54 + 0.76）points，observation group，the incidence of adverse reactions was 9.26%，the indicators are better than the control group，comparing differences between groups was statistically significant（P lt; 0.05）.Conclusion Single drug for S-1 treatment of elderly advanced gastric cancer in the near future curative effect is reliable，less adverse reaction，to vigorously promote the use in clinic. [Key Words] S-1；Elderly；Advanced gastric cancer 胃癌属于临床上最为常见的消化系统恶性肿瘤，中国是全球新发胃癌的高发病率国家，随着我国社会的进步以及人口老龄化的加剧胃癌的发病情况也逐步出现变化，有研究显示65岁以上胃癌发病率在部分地区超过60%，而且以80-84岁为发病高峰[1-2]。老年胃癌患者多数起病较为隐匿，发现时多数已为晚期，丧失了手术机会，因此全身化疗成为晚期胃癌主要的治疗方案，老年人群由于肝肾功能衰退，常合并有多种慢性基础性疾病因此对于化疗的耐受性较差，增加了治疗的风险[3-4]。我院采用单药替吉奥治疗老年晚期胃癌患者取得了满意的治疗效果，现报告