大承气汤加减联合奥曲肽对急性胰腺炎血中降钙素原和c-反应蛋白的影响及临床疗效观察.docVIP

精品论文 参考文献 大承气汤加减联合奥曲肽对急性胰腺炎血中降钙素原和C-反应蛋白的影响及临床疗效观察 乔 虹 娄 华 　　（郑州市中医院 河南 郑州 450007） 　　【摘 要】目的：观察使用大承气汤加减联合奥曲肽治疗急性胰腺炎前后，血中降钙素原（PCT）及C-反应蛋白的变化情况，从而探讨大承气汤对急性胰腺炎患者血中降钙素原及C-反应蛋白影响，并观察其临床疗效。方法：选取本院45例急性胰腺炎患者，随机分为两组，对照组15例使用奥曲肽等常规药物治疗；治疗组30例，在对照组治疗的基础上，给予大承气汤加减经胃管注药。两组患者在确诊后即刻及治疗1d、3d、7d时抽取静脉血，分别检测血降钙素原及C-反应蛋白 (CRP)含量，同时检测两组血常规白细胞计数及血淀粉酶检查。并分析两组生存率、重症患者肠鸣音恢复时间以及住院时间。结果：治疗后两组间PCT、CRP、白细胞计数及血淀???酶方面具有统计学意义(Plt;0.05)。在首次主动排便时间、住院时间之间存在明显差异(Plt;0.01)。结论：大承气汤加减联合奥曲肽可明显降低血PCT及CRP，调节胰酶分泌、抑制炎症因子，在治疗急性胰腺炎中有协同作用，是治疗急性胰腺炎的有效方法之一。 　　【关键词】急性胰腺炎；大承气汤加减；PCT；CRP 　　【中图分类号】R576 【文献标识码】A 【文章编号】1003-5028（2015）6-0437-02 　　The Effect of Dachaihu Decoction combined with octreotide on the Serum procalcitonin and C-reactive protein of Patients with Acute Pancreatitis 　　【Abstract】Objective: To observe the change of procalcitonin (PCT) and C-reactive protein in patients with acute pancreatitis after the treatment of Dachaihu Decoction combined with octreotide and discuss the clinical curative effect of Dachaihu Decoction on acute pancreatitis.Method:45 cases of patients with acute pancreatitis in our hospital, and were randomly divided into two groups, 15 cases with conventional treatment (eg: octreotide)in control group，cases with Dachaihu Decoction by gastric tube in treatment group 30，on the basis of the control group treatment. After treatment of 1 d，3d，7d, two groups was immediately draw blood and detected the level of (PCT) and CRP. As the same time，the two groups all were detected white blood cell count and blood amylase examination and analysis the two groups with survival times，the first time of defecation, hospital stay. Result:Between the two groups after treatment, the difference of PCT,CRP, WBC count and blood amylase has statistical significance ( Plt;0.05).And in terms of the first time of defecation, hospital stay，hospital stay ,two groups have obvious differences ( Plt;0. O1).Conclusion: Dachaihu Decoction combined with octreotide can obviously decrease PCT and CRP to re