【精选】177High Viral Load and Hepatitis B Virus Subgenotype Ce177High Viral Load and Hepatitis B Virus Subgenotype Ce.pdfVIP

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【精选】177High Viral Load and Hepatitis B Virus Subgenotype Ce177High Viral Load and Hepatitis B Virus Subgenotype Ce.pdf

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【精选】177High Viral Load and Hepatitis B Virus Subgenotype Ce177High Viral Load and Hepatitis B Virus Subgenotype Ce

V O L U M E 2 6 N U M B E R 2 J A N U A R Y 1 0 2 0 0 8 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T High Viral Load and Hepatitis B Virus Subgenotype Ce Are Associated With Increased Risk of Hepatocellular Carcinoma Henry Lik-Yuen Chan, Chi-Hang Tse, Frankie Mo, Jane Koh, Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Stephen Lam Chan, Winnie Yeo, Joseph Jao-Yiu Sung, and Tony Shu-Kam Mok From the Department of Medicine and A B S T R A C T Therapeutics, Institute of Digestive Disease; and the Department of Clinical Oncology, The Chinese University of Purpose Hong Kong, Shatin, Hong Kong. We aimed to investigate the impact of hepatitis B virus (HBV) DNA and HBV genotypes/ subgenotypes on the risk of hepatocellular carcinoma (HCC). Submitted July 9, 2007; accepted October 5, 2007. Patients and Methods Supported by Michael Kadoorie Cancer A prospective cohort of patients infected with chronic HBV in a surveillance program for HCC Genetics Research Programme and since 1997 was studied. Ultrasound and alpha-fetoprotein evaluation were regularly performed Research Fund for the Control of Infec- to detect HCC. Risk factors for HCC and the relationship between HBV DNA and HBV tious Diseases (RFCID; application genotypes were determined. number H.L.-Y.C); and Hong Kong Cancer Fund. Results Among 1,006 patients with a median follow-up of 7.7 ye