静电纺再生丝素蛋白改性研究进展.pdfVIP

Vol.48 第48卷 No.05, May. 2011 2011年05月 第05期 研究与技术 静电纺再生丝素蛋白改性研究进展 边瑞琦，熊 杰 (浙江理工大学 先进纺织材料与制备技术教育部重点实验室，杭州 310018) 摘要：在明确了丝素蛋白作为一种生物相容性较好但力学性能较差的基础上，回顾了近年来国内外学者针对静电纺丝素蛋白改性方法 研究，总结出通过物理、化学方法及装置的改变可以对静电纺丝素蛋白进行改性，且改性效果相当明显。提出以共混其他聚合物及制 备形状特殊的纳米纤维等物理方法是对再生丝素蛋白纳米纤维支架比较有效的改性方法。 关键词：静电纺丝；丝素蛋白；组织工程支架；改性 中图分类号：TS102.3 文献标志码：A 文章编号：1001-7003(2011)05-0023-05 Progress in the modification of electrospun regenerated silk fibroin BIAN Rui-qi, XIONG Jie Key Laboratory of Advanced Textile Materials and Manufacturing Technology Ministry of Education, Zhejiang Sci-Tech University, ( Hangzhou 310018, China) Abstract: As we know, silk fibroin plays a good biological compatibility. However, the poor mechanical property has become a great issue to expand its applications. Great attention has been paid by researchers at home and abroad. On the basis of their efforts, it can be concluded that the properties of silk fibroin can be well strengthened using physical or chemical methods, or changing the device during the electrospinning. The viewpoint that physical modify processes including co-blending with other polymers and fabricating fiber with special structures are effective for modification, has been proposed in this paper. Key Words: Electrospinning; Silk fibroin; Tissue engineering scaffolds; Modification 丝素蛋白(SF)是一种资源丰富、性能优良的生物 方法从物理、化学和装置等角度进行了归纳和阐述， [1] 医用材料 ，具有良好的生物相容性和可降解性，利 从而展示了必威体育精装版的研究成果。 用静电纺丝法制备再生丝素蛋白纳米纤维是一种很好 [2] 的制备组织工程支架的方法 。 1