陶瓷膜分离技术应用于中药口服液的研究进展-天津中草药杂志社.pdfVIP

- 184 - Drug Evaluation Research 第 37 卷 第 2 期 2014 年 4 月 陶瓷膜分离技术应用于中药口服液的研究进展 1 2 3 4 1, 3* 伍利华 ，黄 英 ，刘 婷 ，徐玉玲 ，刘 涛 1. 广西中医药大学，广西 南宁 530299 2. 四川新中方医药科技股份有限公司，四川 广元 628000 3. 成都大学，四川 成都 610106 4. 南京中医药大学，江苏 南京 210046 摘 要：中药提取物的纯化工艺直接关系到中药口服液制剂的质量，2010 年版《中国药典》所收载口服液的醇沉除杂法存 在生产工时长、有效成分损失大等缺点。陶瓷膜分离技术不仅有分离、浓缩、纯化和精制的功能，同时具有生产时间短、有 效成分损失小等特点，已作为一项前景十分广阔的高新技术运用到中药制剂的生产过程中。陶瓷膜分离技术应用在中药口服 液生产中可缩短生产流程、提高中药口服液的稳定性和安全性，目前已采用多种方法解决膜污染问题，以解决制约其应用的 瓶颈问题。 关键词：陶瓷膜；中药口服液；分离；纯化；膜污染 中图分类号：R943.4 文献标志码：A 文章编号：1674 - 6376 (2014) 02 - 0184 - 04 DOI: 10.7501/j.issn.1674-6376.2014.02.020 Research progress on ceramic membrane separation technology in application to oral liquid of Chinese materia medica 1 2 3 4 1, 3 WU Li-hua , HUANG Ying , LIU Ting , XU Yu-ling , LIU Tao 1. Guangxi University of Traditional Chinese Medicine, Nanning 530299, China 2. Sichuan Xinzhongfang Pharmaceutical Technologies Inc., Guangyuan 628000, China 3. Chengdu University, Chengdu 610106, China 4. Nanjing University of Chinese Medicine, Nanjing 210046, China Abstract: Purification process of herbal extracts is directly related to the quality of oral liquid of Chinese materia medica (CMM). Most of the CMM oral liquid collected in Chinese Pharmacopeia 2010 were made by the method of alcohol precipitation to remove impurities which has some shortcomings, i.e. long working hours and the massive loss of effective components, etc. The ceramic membrane separation technology not only has the functions like separation, concentration, purification, and refining function, but also has the characteristics such as short production time and the small loss of effective components etc. It will have a broad prospect for the application in the production process of