蛋白分子o-糖基化的研究进展-中国细胞生物学学报.pdfVIP

网络出版时间：2013-10-25 09:51 网络出版地址：/kcms/detail/31.2035.Q0951.001.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(11): DOI: 10.11844/cj cb.2013.11.0148 蛋白分子O-糖基化的研究进展 徐 林 于洪蛟 管 栋 殷一博 梁洪生 张相彤* (哈尔滨医科大学第一附属医院, 哈尔滨150001) 摘要 蛋白分子的氧连接糖基化(O-糖基化)修饰是生物体内必不可少的转录后化学修饰之 一, 其作用方式类似磷酸化, 并且两者之间相互作用, 共同调节生物大分子的活性。O-糖基化修饰 在生物体的转录、翻译、核运输、细胞骨架的形成以及调节细胞器的功能中发挥着重要的作用。 通过影响细胞信号的传导, 在细胞吞噬、炎性细胞的迁移以及细胞内大分子物质的循环中也起着 重要作用。该文主要通过介绍蛋白分子O-糖基化修饰的基础理论以及O-糖基化修饰作用的几个方 面, 来简要阐述O-糖基化修饰在生物体内发挥的作用。 关键词 O-糖基化; 磷酸化; 丝氨酸和苏氨酸残基; 乙酰氨基葡糖转移酶; β-N- 乙酰氨基己 糖苷酶 Research Advances in Protein O-GlcNAcylation Xu Lin, Yu Hongjiao, Guan Dong, Yin Yibo, Liang Hongsheng, Zhang Xiangtong* (The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China) Abstract The O-GlcNAc modification of protein is one of the essential post-translational modifications in the body, which modification mode is similar to the phosphorylation, and they interact with each other and work cooperatively to regulate the activity of biomacromolecules. The O-GlcNAc modification plays an important role in the process of transcription, translation, nucleus transport, cytoskeletal formation and regulating the functions of organelles. Through its effects on the intracellular signal transduction pathways, it is also involved in the processes of phagocytosis, inflammatory cell migration and intracellular macromolecules circulation. In this article, we briefly explained the role of O-GlcNAcylation in the organism mainly through introducing the basic theory of protein