干细胞在细胞移植法治疗心肌损伤中的应用-湖南师范大学.pdfVIP

5 3 ( ) 生命科学研究 Vol . 5 No . 3( Suppl. ) 2 0 0 111 Life Science Research Nov. 2001 X 王跃群, 吴秀山 ( , 410081) : 干细胞是指同时具有自我更新和产生分化细胞的增 性细胞. 干细胞具有分化成多种机体组织细 胞, 包括心肌细胞的潜能. 把胚胎干细胞和成熟组织干细胞分化成心肌细胞的体内和体外实验, 以及把这些分 化出的心肌细胞用于细胞移植来治疗心肌损伤的可能性加以总结. 虽然干细胞用于治疗心肌损伤的细胞移 植疗法具有广阔的前景, 但在临床应用方面仍有很多问题尚待解决. : 干细胞 分化 心肌细胞 细胞移植 : Q291 R329. 1 R622. 9 : A : 1007- 7847( 2001) S0 - 0010- 04 Advances in the Study of Stem Cell-based Transplantation to Treat Cardiac Myocyte Injury WANG Yue- qun, WU Xiu- shan ( College of Lfi e Sciences , Hunan Normal University , Changsha 410081, Hunan, China) Abstract: Stem cells are unique cell populations w ith the ability to undergo both self- renew al and differentiat ion. Stem cells have the ability to form many fully differentiated cells of the body, including cardiac myocytes. In this review , part icular emphasis will be given to summarizing recent studies that focus on the potential of embryonic and adult stem cells for cardiac myocytes differentiation in vitro and in vivo, and the possibility for these differentiated cardiac myocytes to be used for transplantat ion to treat cardiac myocyte injury . Though stem cell- based transplan- tation therapy holds great promise to su ccessfully treat cardiac myocyte injury, many barriers remain in the w ay of successful clinical trials. Key words: stem cell differentiat ion cardiac myocyte cell transplantation ( Lfi e Science Research , 2001, 5( Suppl) : 10~ 13)