经导管介入治疗小儿动脉导管未闭的远期疗效及安全性_32121.doc

经导管介入治疗婴幼儿动脉导管未闭的临床疗效及安全性 郭建军，梁智星，王志斌 （山西医科大学第一医院，山西，太原，030001）【摘要】 目的 总结经导管介入治疗婴幼儿动脉导管未闭（patent?ductus?arterios- us,?PDA）的随访结果，进一步评价其临床疗效和安全性。 方法 对2003年4月至2008年4月接受经导管介入治疗的婴幼儿进行回顾性队列研究。 结果 共有86例PDA患儿接受介入治疗，平均年龄1.8（6个月-3岁）岁，平均体重9.6（4.3-15.4）kg。主动脉弓降部造影显示PDA最窄处直径在1.8-8.2mm之间，平均（4.2±1.3）mm。应用腰径为6-14mm的国产PDA封堵器进行封堵，输送长鞘为6F或7F。86例中成功植入85例（98.8%）。近期并发症3例，其中溶血1例，腹股沟皮下血肿2例，无死亡病例。共有75例在堵堵术后完成1天-3年的随访，随访率为88.2%。所有随访患儿中，封堵器未发生变形、脱落及移位，无严重并发症的发生。 结论 经导管介入治疗婴幼儿PDA疗效确切，安全性好。 【关键词】国产封堵器；心脏导管插入术；动脉导管未闭 Clinical Efficacy anfd safety of transcatheter closure of patent ductus arteriosus using domestic device in infantandchild Guo Jian-jun,Liang Zhi-xing,Wang Zhi-bin (The first hospital of Shanxi medical university,Taiyuan 030001,Shanxi) 【Abstract】?Objectives? To?document?the?follow-up?results?of?transcatheteric?device?occlusion?of?patent?ductus?arteriosus（PDA）in infantandchildthe?safety?and?effectiveness?of?this?method?for?PDA?closure. Methods A retrospe- ctive?cohort?study?was?completed?in?patients with PDA underwent?transcatheter clos- ure?using?domestic?device from April?2003?and?April?2008. Results Transcatheter closure of PDA using?domestic?device was attempted in 86 infantandchild patients. The median age was 1.8 years and median weight was 9.6kg.The PDAs were from 1.8mm to 8.2mm in the narrowest diameter.All PDAs were occluded with 6-14mm domestic?device through 6F or 7F sheaths.Devices were successfully implanted in 85 patients(98.8%).Late complication occurred in 3 patients,including hemolysis in one patient and Inguinal subcutaneous haematomas in two patients,no deaths. Follow-up after device implantation was accomplished in 75 patient(88.2%). The occluder was no deformation、ecclasis and shift of All the infantandchild,and no serious complica- tions. Conclusions? This??follow-up?results?confirm?the?safety?and?effectiveness?of? domestic?device?closure?of?PDAs?in?infantandchild.? 【Key?words】 Domestic made occluder;Heart catheterization; Patent?ductus ar- teriosus;