声化学法制备蛋白质微胶囊的研究进展.docVIP

 声化学法制备蛋白质微胶囊的研究进展# 5 10 15 20 25 30 35 40 45  摘要：以天然蛋白质制备的蛋白质微胶囊被赋予了良好的生物相容性和可降解性，在药物传 输及控制释放等方面有着巨大的潜在应用价值。在众多制备蛋白质微胶囊的方法中，声化学 法具有快速简便，高效环保，药物直接装载，产物纯净无毒等其他方法无可比拟的优点。本 文综述了声化学法制备蛋白质微胶囊的研究进展。阐述了声化学法制备蛋白质微胶囊的方法 与成囊机理，还介绍了不同实验条件，如超声模式、超声功率、超声时间、蛋白质溶液浓度 及油水比等对蛋白质微胶囊制备及性能的影响。并对蛋白质微胶囊的功能化及应用做了介 绍。声化学法制备蛋白质微胶囊为药物载体的制备提供了一个新的研究思路，在生物医药领 域将有广泛的应用。 关键词：高分子化学与物理；蛋白质微胶囊；声化学法；药物载体 中图分类号：O631 rogress on Preparation of Protein Microcapsules by Sonochemical Method LI Zhanfeng1, WANG Bingnan1, ZHONG Shuangling2, CUI Xuejun1, WANG Hongyan1 (1. College of Chemistry, Jilin University, ChangChun 130012; 2. College of Resources and Environment, Jilin Agricultural University, ChangChun 130118) Abstract: Protein microcapsules prepared with natural protein as materials are biocompatible and biodegradability, which would have prospective applications in the fields of drug delivery and controlled release. Among the methods to prepare, the sonochemical method is a very simple, fast, environmental friendly and cost-effective method to fabricate protein microcapsules. The hydrophobic drugs could be encapsulated into protein microcapsules directly via sonochemical method by dissolving drugs in the nontoxic and edible vegetable oil before ultrasonication. The products are non-toxic and safe. This review focused on the progress on preparation of protein microcapsules by sonochemical method. The fabrication and synthesis mechanism of protein microcapsules are described in detail. Experimental conditions such as sonication model, power amplitudes, sonication time, the concentration of protein as well as the ratios of oil-water on the preparation and properties of protein microcapsules are described in detail. Functions of protein microcapsules are also discussed in this review. Such preparation of protein microcapsules by sonochemical method provides us a new, novel idea to preparation of drug carriers and would have prospective applications in biological filed, etc. Keywords: polymer chemist