脯氨酸催化的不对称有机反应_郑欣.pdf

20 11 化 学 进 展 Vol.20 No. 11 2008 11 PROGRESS IN CHE ISTRY Nov., 2008 脯氨酸催化的不对称有机反应* 郑 欣 王永梅* * ( 南开大学化学学院 天津300071) 脯氨酸作为 一种结构简单商品化的廉价小分 手性催化剂, 在多种不对称催化反应中表现 出非常好的催化性能本文综述了近年来脯氨酸直接催化的不对称有机反应涉及Aldol 反应annich 反应 ichael 反应Diels-Alder 反应直接A-胺化反应A-氧胺化反应Baylis-Hillman 反应还原反应和氧化反应的进 展并展望了其应用前景 脯氨酸 催化 不对称反应 + :O62113 5 : A : 1005-281X(2008) 11-1675-12 Proline-Catalyzed Asymmetric Reactions * * Zheng Xin Wang Yongmei ( College of Chemistry, Nankai University, Tianjin 300071, China) Abstract Proline has been gradually recognized as a simple, commercial and cheap chiral catalyst for many asymmetric reactions. The paper reviews recent advances in the development of direct proline-catalyzed asymmetric reactions including Aldol reaction, annich reaction, ichael reaction, Diels-Alder reaction, direct A-amination reaction, A-oxo amination reaction, Baylis-Hillman reaction, reduction reaction and oxidation reaction. It also puts forward the future application of proline. Key words proline; catalysis; asymmetric reaction ,, 1 , , , , [ 1,2] , , , , ; , , , ;, ,; ;, ,; pK a , , , [3] , , ) ) ) ,; : 2008 1, : 2008 2 * (No20472032) * * e-mail:ymw@nankai. edu.cn # 1676 # 化 学 进 展 20 ;, [4] 2 Aldol 2