非典型抗精神病药对男性首发精神分裂症患者泌乳素水平的影响.docVIP

非典型抗精神病药对男性首发精神分裂症患者泌乳素水平的影响 吴春芳，王朔** （华中科技大学同济医学院附属精神卫生中心 武汉 430022） [摘要] 目的：探讨利培酮、氯氮平、奥氮平、喹硫平、阿立哌唑、齐拉西酮6种非典型抗精神病药对男性精神分裂症患者泌乳素水平的影响。方法:将360例精神分裂症患者按照服药情况分为6组，于基线及治疗4、8周末时测定血清泌乳素水平（PRL）。结果：基线时各组间泌乳素水平比较差异无统计学意义（P＞0.05），8周末时与治疗前相比利培酮治疗组泌乳素水平增加最为明显（P＜0.01），氯氮平、奥氮平、喹硫平泌乳素水平显著增加（P＜0.05），阿立哌唑、齐拉西酮泌乳素水平基本没有改变（P＞0.05）。结论：利培酮对泌乳素水平升高最为明显，氯氮平、奥氮平、喹硫平影响次之，而阿立哌唑与齐拉西酮对泌乳素水平基本无影响。 [关键词] 非典型抗精神病药，精神分裂症，泌乳素 Effects of atypical antipsychotic drugs on prolactin levels in male patients with first episode schizophrenia Wu Chunfang ，Wang Shuo * * （mental health center, Tongji Medical College, Huazhong University of Science and Technology，Wuhan ，430022） [Abstract] Objective: To observe the effects of risperidone, clozapine, olanzapine, quetiapine, aripiprazole, ziprasidone 6 [this is four drugs, and 2? Effect of atypical antipsychotic drugs on prolactin levels in male patients with schizophrenia. Methods: 360 patients with schizophrenia were divided into 6 groups according to the treatment. The serum prolactin levels (PRL) were measured at baseline and at 4 and 8 weeks. Results: baseline groups between prolactin levels and the difference no statistical significance (P 0.05), 8 weeks before and after treatment compared with risperidone treatment group, prolactin levels increased significantly (P 0.01), clozapine, olanzapine, quetiapine quetiapine lactation hormone levels increased significantly (P 0.05), aripiprazole, ziprasidone lactation hormone levels did not change (P 0.05). Conclusions: risperidone on prolactin levels were the most obvious, clozapine, olanzapine, quetiapine influence the second, and aripiprazole and ziprasidone on lactation hormone levels of no effect. [Key words] atypical antipsychotics, schizophrenia, prolactin 近年来，非典型抗精神病药物以其确切的疗效在临床上得到了广泛应用，其对精神分裂症患者泌乳素水平的影响也逐渐受到重视。但是针对不同抗精神病药对泌乳素水平影响的比较上已有文献提及，但多为2种药物比较，而多种抗精神病药所致泌乳素水平变化的同时比较报道甚少。现对在华中科技大学同济医学院附属精神卫生中心住院期间单用氯氮平、利培酮、喹硫平、阿立哌唑、齐拉西酮、奥氮平治疗的首发精神分裂症患者血清泌乳素水平进行回顾性研究，结果报告如下。 1 对象与方法 1.1 研究对象 来自2014年9月至2014年12月在我