二甲双胍对女性肥胖型糖尿病患者血脂及体质量影响.docVIP

二甲双胍对女性肥胖型糖尿病患者血脂及体质量影响 　　　【摘要】 目的 观察二甲双胍对女性肥胖型糖尿病患者血脂与体质量的影响。方法 选择女性肥胖型糖尿病患者120例，随机分为两组，实验组给予二甲双胍，对照组给予吡格列酮。两组患者在治疗前和治疗12周后均检测空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HBAlc)、血脂(TC、TG、HDL-C、LDL-C)及体重指数(BMI)。结果 二甲双胍及吡格列酮组患者血清 FBG、HBAlc、TG、LDL-C、FINS水平与治疗前比较均明显降低(Plt;0．01)，二甲双胍实验组BMI与治疗前比较亦显著降低(Plt;0．01)。二甲双胍组与吡格列酮对照组比较，患者血清 FBG、HBAlc、TG、LDL-C水平和BMI均明显降低(Plt;0．01)，而FINS、TC、HDL-C含量则无显著影响(Pgt;0．05)。结论 二甲双胍能明显改善女性肥胖型糖尿病患者血脂水平和体质量。 　　【关键词】二甲双胍；肥胖型糖尿病；血脂；体质量 　　 　　【Abstract】 Objective To investigate the effect of metformin for blood lipid and body mass of female obesity-diabetes patients.Methods Female obesity-diabetes patients(n=120)were randomly divided into two groups(n=60)：experimental group and control group.The experimental group were given metformin,and the control group were given pioglitazone.The fasting blood glucose(FPG),fasting insulin(FINS),glycosylated hemoglobin(HBAlc),blood lipid(TC,TG,HDL-C,LDL-C)and body mass index(BMI)of patients of two groups were measured before and 12 weeks after treatment.Results The level of serum FPG,HBAIC,TG,LDL-C and FINS of patients of metformin and pioglitazone groups were significantly lower than those of before treatment(Plt;0．01).The BMI of metformin experimental group were significantly lower than those of before treatment(Plt;0．01).The level of serum FBG,HBAIC,TG,LDL-C and BMI of patients of metformin experimental group,compared with pioglitazone control group,were significantly decreased(Plt;0．01),whereas,the level of serum FINS,TC and HDL-C had no significant influence(Pgt;0．05).Conclusion Metformin could obviously improve the level of blood lipid and BMI of female obesity-diabetes. 　　【Key words】Metformin;obesity-diabetes;Blood lipid;Body mass 　　 　　女性肥胖型糖尿病是导致心血管病并发症死亡的主要原因之一，二甲双胍作为治疗2型糖尿病（T2DM）的口服降糖药物，除具有抑制肝糖原输出、加强周围组织对葡萄糖的利用外，还可改善胰岛素抵抗，但二甲双胍对女性肥胖型糖尿病患者血脂水平和体质量的影响鲜见报道，本文系统观察了二甲双胍对女性肥胖型糖尿病患者血脂与体质量的影响，为糖尿病心血管病并发症的防治提供参考。 　　1 对象与方法 　　1．1 研究对象 女性肥胖型糖尿病患者120例，平均(55±5．56)岁。入选时所有患者均符合1999年WHO诊断标准，并满足以下条件：①首诊时空腹血糖(FPG)在7~12 m