design of wide-spectrum inhibitors targeting coronavirus main proteases以前主要针对冠状病毒蛋白酶抑制剂的设计.pdfVIP

Open access, freely available online PLoS BIOLOGY Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases 1,2 3 1,2 1,2 1,2 4 1,2 1,2 Haitao Yang , Weiqing Xie , Xiaoyu Xue , Kailin Yang , Jing Ma , Wenxue Liang , Qi Zhao , Zhe Zhou , Duanqing Pei5 6 7 8 9 1,2 4 , John Ziebuhr , Rolf Hilgenfeld , Kwok Yung Yuen , Luet Wong , Guangxia Gao , Saijuan Chen , Zhu Chen4, Dawei Ma3*, Mark Bartlam1,2, Zihe Rao1,2* 1 Tsinghua-IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing, China, 2 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 3 State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China, 4 Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Second Medical University, Shanghai, China, 5 Guangzhou Institute of ¨ ¨ Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 6 Institute of Virology and Immunology, University of Wurzburg, Wurzburg, Germany, 7 Institute ¨ ¨ for Biochemistry, University of Lubeck, Lubeck, Germany, 8 Department of Microbiology, University of Hong Kong, Hong Kong, China, 9 Department of Chemistry, Inorganic Chemistry Laboratory, University