design of targeted b cell killing agents设计有针对性的b细胞杀死代理.pdfVIP

Design of Targeted B Cell Killing Agents 1. 1,2. 1 1 Alexey V. Stepanov , Alexey A. Belogurov, Jr. , Natalia A. Ponomarenko , Oleg A. Stremovskiy , 3 3 4 1 1 Leonid V. Kozlov , Anna M. Bichucher , Sergey E. Dmitriev , Ivan V. Smirnov , Olga G. Shamborant , 5 2 4 6 Dmitry S. Balabashin , Lidia P. Sashchenko , Alexander G. Tonevitsky , Alain Friboulet , Alexander G. 1,2 1 Gabibov *, Sergey M. Deyev * 1 M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, 2 Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia, 3 G.N. Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russia, 4 Belozersky Institute of Physico-Chemical ´ ` Biology, Moscow State University, Moscow, Russia, 5 Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia, 6 Universite de Technologie de Compiegne, ` Compiegne, France Abstract B cells play an important role in the pathogenesis of both systemic and organ-specific autoimmune diseases. Autoreactive B cells not only produce autoantibodies, but also are capable to efficiently present specific autoantigens to T cells. Furthermore, B