consistency and diversity of spike dynamics in the neurons of bed nucleus of stria terminalis of the rat a dynamic clamp study飙升的一致性和多样性动态床核神经元的条痕terminalis鼠动态夹研究.pdfVIP

Consistency and Diversity of Spike Dynamics in the Neurons of Bed Nucleus of Stria Terminalis of the Rat: A Dynamic Clamp Study ¨ 1,4 2,5 3 2 2 Attila Szucs *, Fulvia Berton , Thomas Nowotny , Pietro Sanna , Walter Francesconi 1 BioCircuits Institute, University of California San Diego, La Jolla, California, United States of America, 2 Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, United States of America, 3 Centre for Computational Neuroscience and Robotics, School of Informatics, University of Sussex, Brighton, United Kingdom, 4 Department of Experimental Zoology, Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary, 5 Department of Biology, University of Pisa, Pisa, Italy Abstract Neurons display a high degree of variability and diversity in the expression and regulation of their voltage-dependent ionic channels. Under low level of synaptic background a number of physiologically distinct cell types can be identified in most brain areas that display different responses to standard forms of intracellular current stimulation. Nevertheless, it is not well understood how biophysically different neurons process synaptic inputs in natural conditions, i.e., when experiencing intense synaptic bombardment in vivo. While distinct cell types might process synaptic inputs into different patterns of action potentials representing specific ‘‘motifs’’ of network activity, standard methods of electrophysiology are not well suited to resolve such questions. In the current paper we performed dynamic clamp experiments with simulated synaptic inputs that were presented to three types of neuro