cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathwayscre-mediated压力影响sirtuin蛋白表达水平,过氧物酶体生物起源和新陈代谢,抗氧化剂和炎性信号通路.pdfVIP

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2017-09-12 发布于上海
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cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathwayscre-mediated压力影响sirtuin蛋白表达水平,过氧物酶体生物起源和新陈代谢,抗氧化剂和炎性信号通路.pdf

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cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathwayscre-mediated压力影响sirtuin蛋白表达水平,过氧物酶体生物起源和新陈代谢,抗氧化剂和炎性信号通路

Cre-Mediated Stress Affects Sirtuin Expression Levels, Peroxisome Biogenesis and Metabolism, Antioxidant and Proinflammatory Signaling Pathways 1 1 1¤a 1¤b 1 2 Yu Xiao , Srikanth Karnati , Guofeng Qian , Anca Nenicu , Wei Fan , Svetlin Tchatalbachev , ¨ 2 2 3 ¨ 1¤c 1 Anita Holand , Hamid Hossain , Florian Guillou , Georg H. Luers , Eveline Baumgart-Vogt * 1 Institute for Anatomy and Cell Biology II, Justus Liebig University Giessen, Giessen, Germany, 2 Institute for Medical Microbiology, Justus Liebig University Giessen, ´ Giessen, Germany, 3 INRA UMR 85, CNRS UMR 6175, Universite Franc¸ois Rabelais de Tours, IFCE Physiologie de la Reproduction et des Comportements, Nouzilly, France Abstract Cre-mediated excision of loxP sites is widely used in mice to manipulate gene function in a tissue-specific manner. To analyze phenotypic alterations related to Cre-expression, we have used AMH-Cre-transgenic mice as a model system. Different Cre expression levels were obtained by investigation of C57BL/6J wild type as well as heterozygous and homozygous AMH-Cre-mice. Our results indicate that Cre-expression itself in Sertoli cells already has led to oxidative stress and lipid peroxidation (4-HNE lysine adducts), inducing PPARa/c, peroxisome proliferation and alterations of peroxisome biogenesis (PEX5, PEX13 and PEX14) as well as metabolic proteins (ABCD1, ABCD3, MFP1, thiolase B, catalase). In addition to the strong catala