coumestrol, bisphenol-a, ddt, and tcdd modulation of interleukin-2 expression in activated cd+4 jurkat t cellscoumestrol、双酚a、滴滴涕,tcdd调制白介素2 cd + 4 t细胞jurkat表达激活.pdfVIP
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coumestrol,bisphenol-a,ddt,andtcddmodulationofinterleukin-2expressioninactivatedcd4jurkattcellscoumestrol、双酚a、滴滴涕,tcdd调制白介素2cd4t细胞jurkat表达激活
Int. J. Environ. Res. Public Health 2004, 1, 3–11 International Journal of Environmental Research and Public Health ISSN 1660-4601 © 2004 by MDPI Coumestrol, Bisphenol-A, DDT, and TCDD Modulation of Interleukin-2 Expression in Activated CD+4 Jurkat T Cells 1, 2 1 2* Kenneth Ndebele , Paul B. Tchounwou , and Robert W. McMurray 1Molecular Toxicology Research Laboratory, NIH- Center for Environmental Health, School of Science and Technology, Jackson State University, 1400 Lynch Street, P.O. Box 18540, Jackson, Mississippi, USA. Email: paul.b.tchounwou@ 2Rheumatology Section, G.V. (Sonny) Montgomery V.A. Hospital and Division of Rheumatology and Molecular Immunology, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. * Correspondence to Dr. Robert W. McMurray. Email: rmcmurray@ Received: 20 September 2003 / Accepted: 20 November 2003 / Published: 29 February 2004 Abstract: Endogenous estrogens are known to modulate several components of immune response, including interleukin-2 (IL-2) production. IL-2 is a cytokine that plays an important role in adaptive immune responses. These responses may be modulated by xenoestrogens such as coumestrol, bisphenol A (BPA), DDT, and TCDD.
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