cortical gyrification and sulcal spans in early stage alzheimers disease皮质gyrification和沟的跨越早期阿尔茨海默氏症.pdfVIP

Cortical Gyrification and Sulcal Spans in Early Stage Alzheimer’s Disease 1,2,3 2,3 2,3 1 1 4 Tao Liu , Darren M. Lipnicki , Wanlin Zhu , Dacheng Tao , Chengqi Zhang , Yue Cui , Jesse S. Jin1,4*, Perminder S. Sachdev2,3, Wei Wen2,3* 1 Centre for Quantum Computation and Intelligent System, Faculty of Engineering and Information Technology, University of Technology Sydney, New South Wales, Australia, 2 Brain and Ageing Research Program, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia, 3 Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia, 4 School of Design, Communication I.T., The University of Newcastle, New South Wales, Australia Abstract Alzheimer’s disease (AD) is characterized by an insidious onset of progressive cerebral atrophy and cognitive decline. Previous research suggests that cortical folding and sulcal width are associated with cognitive function in elderly individuals, and the aim of the present study was to investigate these morphological measures in patients with AD. The sample contained 161 participants, comprising 80 normal controls, 57 patients with very mild AD, and 24 patients with mild AD. From 3D T1-weighted brain scans, automated methods were used to calculate an index of global cortex gyrification and the width of five individual sulci: superior frontal, intra-parietal, superior temporal, central, and Sylvian fissure. We found that global cortex gyrification decreased with increasing severity of AD, and that the width of all individual sulci investigated other than the intra-parietal sulcus was greater in patients with mild AD than in controls. We also found that cognitive functioning,