vascular endothelial expression of indoleamine 2,3-dioxygenase 1 forms a positive gradient towards the feto-maternal interface血管内皮表达吲哚胺2,3-dioxygenase 1对feto-maternal界面形成一个积极的梯度.pdfVIP

Vascular Endothelial Expression of Indoleamine 2,3- Dioxygenase 1 Forms a Positive Gradient towards the Feto-Maternal Interface 1 1 2 1 1 3 Astrid Blaschitz , Martin Gauster , Dietmar Fuchs , Ingrid Lang , Petra Maschke , Daniela Ulrich , Eva 4 5 6 1 1 Karpf , Osamu Takikawa , Michael G. Schimek , Gottfried Dohr , Peter Sedlmayr * 1 Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria, 2 Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria, 3 Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria, 4 Institute of Pathology, Center for Applied Biomedicine, Medical University of Graz, Graz, Austria, 5 Laboratory of Radiation Safety, National Institute of Longevity Science, National Center for Geriatrics and Gerontology, Obu City, Japan, 6 Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria Abstract We describe the distribution of indoleamine 2,3-dioxygenase 1 (IDO1) in vascular endothelium of human first-trimester and term placenta. Expression of IDO1 protein on the fetal side of the interface extended from almost exclusively sub- trophoblastic capillaries in first-trimester placenta to a nearly general presence on villous vascular endothelia at term, including also most bigger vessels such as villous arteries and veins of stem villi and vessels of the chorionic plate. Umbilical cord vessels were generally negative for IDO1 protein. In the fetal part of the placenta positivity for IDO1 was restricted to