有哪些信誉好的足球投注网站vaccinia virus e3 protein prevents the antiviral action of isg15牛痘病毒e3蛋白防止isg15的抗病毒作用.pdfVIP
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vaccinia virus e3 protein prevents the antiviral action of isg15牛痘病毒e3蛋白防止isg15的抗病毒作用
Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15 1,2 ´ 1 3 3 1 Susana Guerra *, Ana Caceres , Klaus-Peter Knobeloch , Ivan Horak , Mariano Esteban * ´ ´ 1 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologıa CSIC, Campus Universidad Autonoma, Madrid, Spain, 2 Department of Preventive ´ Medicine and Public Health, Universidad Autonoma, Madrid, Spain, 3 Abteilung Molekulare Genetik, Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany Abstract The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense molecule against vaccinia virus (VACV) infection. In MEFs, the growth of replication competent Western Reserve (WR) VACV strain was affected by the absence of ISG15, but in addition, virus lacking E3 protein (VVDE3L) that is unable to grow in ISG15+/+ cells replicated in ISG15-deficient cells. Inhibiting ISG15 with siRNA or promoting its expression in ISG15 2/ 2 cells with a lentivirus vector showed that VACV replication was controlled by ISG15. Immunoprecipitation analysis revealed that E3 binds ISG15 through its C-terminal domain. The VACV antiviral action of ISG15 and its interaction with E3 are events independent of PKR (double-stranded RNA-dependent protein kinase). In mice lacking ISG15, infection with VVDE3L caused significant disease and mortality, an effect not obse
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