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use of a mathematical model of autopoietic maintenance of pulmonary alveolar integrity to show a possible relationship between epithelial-mesenchymal transition and the genesis of emphysema and fibrosis英文论文.pdf

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use of a mathematical model of autopoietic maintenance of pulmonary alveolar integrity to show a possible relationship between epithelial-mesenchymal transition and the genesis of emphysema and fibrosis英文论文

Open Journal of Molecular and Integrative Physiology, 2011, 1, 23-28 OJMIP doi:10.4236/ojmip.2011.12004 Published Online August 2011 (http://www.SciRP.org/journal/ojmip/). Use of a mathematical model of autopoietic maintenance of pulmonary alveolar integrity to show a possible relationship between epithelial-mesenchymal transition and the genesis of emphysema and fibrosis Kyongyob Min, Keita Hosoi, Yoshinori Kinoshita, Satoshi Hara, Hiroyuki Degami, Tetsuo Takada, Takahiko Nakamura Department of Internal Medicine, Itami City Hospital, Hyogo, Japan. Email: in1007@poh-osaka-med.ac.jp Received 20 June 2011; revised 15 July 2011; accepted 1 August 2011. ABSTRACT suggested a close relationship between alveolar em- physema and fibrosis and EMT in lungs affected by Rationale : There is accumulating evidence that a chronic obstructive pulmonary disease. group of stem/progenitor cells (SPCs) maintain al- veolar epithelial integrity. Pulmonary emphysema is Keywords: Autopoiesis; Pulmonary Emphysema; characterized by the histological finding of the loss of Pulmonary Fibrosis; Pulmonary Stem/Progenitor Cells alveolar epithelial integrity along with corresponding bronchiolar fibrosis. Objectives: Based on the concept 1. INTRODUCTION of autopoiesis (the capacity to produce oneself), we proposed a mathematical model in the maintenance The current enthusiasm for stem cell research derives of alveolar epithelial integrity as related to the gene- from the hope that damaged or diseased tissues, includ- sis of pulmonary emphysema and fibrosis. Methods :