the clinical implications of adult-onset henoch-schonelin purpura成人henoch-schonelin紫癜的临床意义.pdfVIP

Jithpratuck et al. Clinical and Molecular Allergy 2011, 9:9 /content/9/1/9 CMA REVIEW Open Access The clinical implications of adult-onset henoch-schonelin purpura 1 2 1 2 1 1,3* Warit Jithpratuck , Yasmin Elshenawy , Hana Saleh , George Youngberg , David S Chi and Guha Krishnaswamy Abstract Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Pathologically, it can be considered a form of immune complex-mediated leukocytoclastic vasculitis (LCV) involving the skin and other organs. Though it primarily affects children (over 90% of cases), the occurrence in adults has been rarely reported. Management often involves the use of immunomodulatory or immune- suppressive regimens. Introduction this is truly a multisystem disease and may result in con- Henoch-Schonlein Purpura (HSP) is a small vessel vas- siderable morbidity and mortality in some patients. A culitis mediated by IgA-immune complex deposition. It variety of disorders have been associated with HSP is characterized by the clinical tetrad of non-thrombocy- including infection with Helicobacter pylori, hepatitis B topenic palpable purpura, abdominal pain, arthritis and and certain malignancies. The following review describes renal involvement [1]. Pathologically, it can be consid- the course, complications and management of adult- ered a f