the allure of the epigenome表观基因组的魅力.pdfVIP

Attar Genome Biology 2012, 13:419 /2012/13/10/419 E D I TO R I A L The allure of the epigenome Naomi Attar he Oxford English Dictionary dates the word ‘genome’ data) and DEseq [3] (RNA-seq data). he challenge of to 1926 but has not yet seen it to include the term designing bioinformatics tools for the ever expanding ‘epigenome’ in its illustrious pages (where it would reside number of DNA methylation genome-wide proiling handsomely between ‘epigenist’ and ‘epigenous’). his methods has been taken up by many bioinformatics labs diferential treatment relects a state of afairs in which [4]. In the past few months, for example, Genome Biology the epigenome has yet to iniltrate the popular has published SWAN [5], a method for reducing imagination, but belies the recent explosion of technical variation in data from the cutting-edge Illumina epigenomics in the scientiic literature, where as many as HumanMethylation450 BeadChip platform, and Bis-SNP 70% of all abstracts featuring ‘epigenome’ have been [6], a method for calling SNPs in bisulite sequencing published within the last three years. data, which also has the advantage of improving the he present-day proliferation in epigenomics, in the accuracy of methylation calls. exploration of the dynamic regulatory layers that insulate he special issue now adds a number of powerful new the genome’s static DNA sequence, has been enabled by tools to assist those working with DNA methylation data. novel high-throughput techniques for interrogating the BatMeth [7] is a mapper for Illumina and