temporal trends in serum concentrations of polychlorinated dioxins, furans, and pcbs among adult women living in chapaevsk, russia a longitudinal study from 2000 to 2009时间趋势血清浓度的多氯二恶英、呋喃、和多氯联苯在chapaevsk成年女性的生活中,俄罗斯从2000年到2009年的纵向研究.pdfVIP

Humblet et al. Environmental Health 2011, 10:62 /content/10/1/62 RESEARCH Open Access Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009 1 2,3 4,5 1,6 7 8,9 Olivier Humblet , Oleg Sergeyev , Larisa Altshul , Susan A Korrick , Paige L Williams , Claude Emond , 10 1 11 12 13 13 Linda S Birnbaum , Jane S Burns , Mary M Lee , Boris Revich , Andrey Shelepchikov , Denis Feshin and Russ Hauser1* Abstract Background: The present study assessed the temporal trend in serum concentrations of polychlorinated dibenzo- p-dioxins, dibenzofurans, and biphenyls (PCBs) among residents of a Russian town where levels of these chemicals are elevated due to prior industrial activity. Methods: Two serum samples were collected from eight adult women (in 2000 and 2009), and analyzed with gas chromatography-high-resolution mass spectrometry. Results: The average total toxic equivalency (TEQ) decreased by 30% (from 36 to 25 pg/g lipid), and the average sum of PCB congeners decreased by 19% (from 291 to 211 ng/g lipid). Total TEQs decreased for seven of the eight women, and the sum of PCBs decreased for six of eight women. During this nine year period, larger decreases in serum TEQs and PCBs were found in women with greater increases in body mass index. Conclusions: This study provides suggestive evidence that average serum concentrations of dioxins, furans, and PCBs are decreasing over time among residents of this town. Introduction