targeting fgfr4 inhibits hepatocellular carcinoma in preclinical mouse models针对fgfr4抑制肝细胞癌在临床前小鼠模型.pdfVIP

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targeting fgfr4 inhibits hepatocellular carcinoma in preclinical mouse models针对fgfr4抑制肝细胞癌在临床前小鼠模型.pdf

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targeting fgfr4 inhibits hepatocellular carcinoma in preclinical mouse models针对fgfr4抑制肝细胞癌在临床前小鼠模型

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models 1. 2 .¤a 2 3 3 Dorothy M. French , Benjamin C. Lin * , Manping Wang , Camellia Adams , Theresa Shek , ¨ 1 5 1 2¤b 3 1 Kathy Hotzel , Brad Bolon , Ronald Ferrando , Craig Blackmore , Kurt Schroeder , Luis A. Rodriguez , 4 4 2 2¤a Maria Hristopoulos , Rayna Venook , Avi Ashkenazi , Luc R. Desnoyers 1 Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America, 2 Department of Molecular Oncology, Genentech, Inc., South San Francisco, California, United States of America, 3 Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, United States of America, 4 Department of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America, 5 GEMpath, Inc., Longmont, Colorado, United States of America Abstract The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes. It is also well documented that dysregulation of FGF-FGFR signaling may have important roles in tumor development and progression. The FGFR4–FGF19 signaling axis has been implicated in the development of hepatocellular carcinomas (HCCs) in mice, and potentially in humans. In this study, we demonstrate that