有哪些信誉好的足球投注网站targeted morphoproteomic profiling of ewings sarcoma treated with insulin-like growth factor 1 receptor (igf1r) inhibitors responseresistance signatures目标morphoproteomic剖析尤文氏肉瘤的治疗胰岛素样生长因子1受体(igf1r)抑制剂responseresistance签名.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
targeted morphoproteomic profiling of ewings sarcoma treated with insulin-like growth factor 1 receptor (igf1r) inhibitors responseresistance signatures目标morphoproteomic剖析尤文氏肉瘤的治疗胰岛素样生长因子1受体(igf1r)抑制剂responseresistance签名
Targeted Morphoproteomic Profiling of Ewing’s Sarcoma Treated with Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures 1,2 2 3 4 4 5 Vivek Subbiah *, Aung Naing , Robert E. Brown , Helen Chen , Laurence Doyle , Patricia LoRusso , 6 1 2 Robert Benjamin , Pete Anderson , Razelle Kurzrock 1 Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2 Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, Texas, 3 Department of Pathology and Laboratory Medicine, UT Health, University of Texas–Houston Medical School, Houston, Texas, 4 Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, 5 Wayne State University–Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, 6 Division of Cancer Medicine, Department of Sarcoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas Abstract Background: Insulin-like growth factor 1 receptor (IGF1R) targeted therapies have resulted in responses in a small number of patients with advanced metastatic Ewing’s sarcoma. We performed morphoproteomic profiling to better understand response/resistance mechanisms of Ewing’s sarcoma to IGF1R inhibitor-based therapy. Methodology/Principal Findings: This pilot study assessed two patients with advanced Ewing’s sarcoma treated with IGF1R antibody alone followed by combined IGF1R inhibitor plus mammalian target of rapamycin (mTOR) inhibitor treatment once resistance to single-agent IGF1R inhibitor developed. Immunohistochemical probes were applie
您可能关注的文档
- synthesis and x-ray structure of a new pyrrolo[1,2-b]-pyridazine derivative合成和x射线结构新的pyrrolo[1,2 b]哒嗪衍生物.pdf
- synthesis method for thiosulfonate and report of its insecticidal activity in anagasta kuehniella (lepidoptera pyralidae)合成方法thiosulfonate和报告的杀虫活动anagasta kuehniella(鳞翅目pyralidae).pdf
- synthesis methods, microscopy characterization and device integration of nanoscale metal oxide semiconductors for gas sensing合成方法,显微镜表征和设备集成的纳米金属氧化物半导体气体传感.pdf
- synthesis and x-ray crystal structure of the first pure and air-stable salt of peroxymonosulphuric acid (ph)4phso5合成和x射线晶体结构的第一个纯和air-stable盐peroxymonosulphuric酸(ph)4 phso5.pdf
- synthesis and α-glucosidase inhibitory mechanisms of bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a potential marine bromophenol α-glucosidase inhibitor合成和α-glucosidase抑制机制的bis(2 3-dibromo-4 5-dihydroxybenzyl)醚、潜在海洋溴酚α-glucosidase抑制剂.pdf
- synthesis of [(4-chloro-5h-1,2,3-dithiazol-5-ylidene)amino]azines合成[(4-chloro-5h-1 2 3-dithiazol-5-ylidene)氨基]吖嗪.pdf
- synthesis of 1-(4-trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-r-thiazol-4-yl)-1h-pyrroles via chain heterocyclization合成1 -(4-trifluoromethoxyphenyl)2,5-dimethyl-3 -(2-r-thiazol-4-yl)1通过链heterocyclization h-pyrroles.pdf
- synthesis of 1,2,3-triazole derivatives and in vitro antifungal evaluation on candida strains合成1 2 3-triazole衍生品和体外抗真菌评价念珠菌菌株.pdf
- synthesis of 1-[(2-oxonaphthalen-1(2h)-ylidene)methyl]urea合成1 -[(2-oxonaphthalen-1(2 h)-ylidene)甲基]尿素.pdf
- synthesis of 1α,25-dihydroxyvitamin d analogues featuring a s2-symmetric cd-ring core合成1α,25-dihydroxyvitamin d类似物以s2-symmetric cd - r核心.pdf
- targeting of mitochondria-endoplasmic reticulum by fluorescent macrocyclic compounds针对荧光mitochondria-endoplasmic网的大环化合物.pdf
- targeting mitochondrial cell death pathway to overcome drug resistance with a newly developed iron chelate针对线粒体细胞死亡途径克服耐药性新开发的铁螯合物.pdf
- targeting of a chlamydial protease impedes intracellular bacterial growth针对衣原体蛋白酶的阻碍细胞内细菌生长.pdf
- targeting of pseudorabies virus structural proteins to axons requires association of the viral us9 protein with lipid rafts针对假狂犬病病毒的病毒结构蛋白轴突需要协会us9蛋白质与脂质筏.pdf
- targeting physical activity promotion in general practice characteristics of inactive patients and willingness to change针对体育活动促进病人一般实践活动的特点和意愿去改变.pdf
- targeting of mycobacterium tuberculosis heparin-binding hemagglutinin to mitochondria in macrophages针对结核分枝杆菌heparin-binding血凝素在巨噬细胞中线粒体.pdf
- targeting oncogenic protein-protein interactions by diversity oriented synthesis and combinatorial chemistry approaches针对多样性导向合成和组合化学致癌蛋白质相互作用的方法.pdf
- targeting protective autophagy exacerbates uv-triggered apoptotic cell death针对保护性自噬加剧uv引起的凋亡细胞死亡.pdf
- targeting protein-protein interactions for parasite control针对寄生虫控制蛋白质-蛋白质之间的关系.pdf
- targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (mia) protein inhibition针对黑色素瘤转移和免疫抑制的新模式(mia)蛋白抑制黑素瘤抑制活动.pdf
文档评论（0）