targeted therapy database (ttd) a model to match patients molecular profile with current knowledge on cancer biology靶向治疗数据库(运输大亨)模型匹配病人的癌症生物学与当前知识分子形象.pdfVIP

Targeted Therapy Database (TTD): A Model to Match Patient’s Molecular Profile with Current Knowledge on Cancer Biology 1 2 3,4,5 1 1 Simone Mocellin *, Jeff Shrager , Richard Scolyer , Sandro Pasquali , Daunia Verdi , Francesco M. 6 1 2 1 1 Marincola , Marta Briarava , Randy Gobbel , Carlo Rossi , Donato Nitti 1 Clinica Chirurgica Generale 2, Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy, 2 Symbolic Systems Program, Stanford University, and CollabRx, Inc., Palo Alto, California, United States of America, 3 Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia, 4 Melanoma Institute Australia, Sydney, Australia, 5 Discipline of Pathology, The University of Sydney, Sydney, Australia, 6 Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, and Center for Human Immunology, National Institutes of Health, Bethesda, Maryland, United States of America Abstract Background: The efficacy of current anticancer treatments is far from satisfactory and many patients still die of their disease. A general agreement exists on the urgency of developing molecularly targeted therapies, although their implementation in the clinical setting is in its infancy. In fact, despite the wealth of preclinical studies addressing these issues, the difficulty of testing each targeted therapy hypothesis in the clinical arena represents an intrinsic obstacle. As a consequence, we are witnessing a paradoxical situation where most hypotheses about the molecular and cellular biology of cancer remain clinically untested and therefore do not translate int