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synthesis, spectroscopic properties and antipathogenic activity of new thiourea derivatives合成、光谱特性和antipathogenic活动新的硫脲衍生物
Molecules 2011, 16, 7593-7607; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Spectroscopic Properties and Antipathogenic Activity of New Thiourea Derivatives Carmen Limban 1, Luminita Marutescu 2 and Mariana Carmen Chifiriuc 2,3,* 1 Pharmaceutical Chemistry Department, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania; E-Mail: carmen_limban@ 2 Microbiology Department, Faculty of Biology, University of Bucharest, Ale. Portocalelor 1-4, Bucharest 60101, Romania; E-Mail: lumi_dascalu@ 3 National Institute for Research and Development in Microbiology and Immunology “Cantacuzino”, Spl. Independentei 103, Bucharest 060031, Romania * Author to whom correspondence should be addressed; E-Mail: carmen_balotescu@. Received: 4 August 2011; in revised form: 29 August 2011 / Accepted: 1 September 2011 / Published: 6 September 2011 Abstract: A number of acylthioureas, 2-((4-methylphenoxy)methyl)-N-(aryl- carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro- phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluorophenyl, 2,4,5-trifluoro- phenyl, 2,4,6-trifluorophenyl) have been synthesized, characterized by elemental analysis, IR and NMR spectroscopy and tested for their interaction with bacterial cells in free and adherent state. The anti-pathogenic activity was correlated with the presence
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