synthesis, tautomeric structure and antimicrobial activity of 3-arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1h)-diones合成、互变异构的结构和抗菌活性3-arylhydrazono-4-phenyl -(1、2、4)-triazepino[2、3]quinazoline-2,7(1 h)-diones.pdfVIP

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synthesis, tautomeric structure and antimicrobial activity of 3-arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1h)-diones合成、互变异构的结构和抗菌活性3-arylhydrazono-4-phenyl -(1、2、4)-triazepino[2、3]quinazoline-2,7(1 h)-diones.pdf

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synthesis, tautomeric structure and antimicrobial activity of 3-arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1h)-diones合成、互变异构的结构和抗菌活性3-arylhydrazono-4-phenyl -(1、2、4)-triazepino[2、3]quinazoline-2,7(1 h)-diones

Molecules 2012, 17, 8483-8493; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline- 2,7(1H)-diones Thoraya Abdel Reheem Farghaly 1, Mastoura Mohamed Edrees 2,† and Mosselhi Abdelnabi Mosselhi 1,3,* 1 Department of Chemistry, Faculty of Science, University of Cairo, Giza 12311, Egypt; E-Mail: Thoraya-f@ 2 Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt; E-Mail:mmohamededrees@ 3 Department of Chemistry, Faculty of Science, Taif University, Taif-888, Saudi Arabia † Present address: Department of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, ABHA-61413, Saudi Arabia. * Author to whom correspondence should be addressed; E-Mail: mosselhi2008 @. Received: 24 May 2012; in revised form: 25 June 2012 / Accepted: 3 July 2012 / Published: 13 July 2012 Abstract: A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4- phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria. Keywords: azo-hydrazone; tautomerism;