synthesis of some new bis-schiff bases of isatin and 5-fluoroisatin in a water suspension medium合成一些新的bis-schiff基地靛红和5-fluoroisatin水悬浮介质.pdfVIP

Molecules 2006, 11, 59–63 molecules ISSN 1420-3049 Synthesis of Some New bis-Schiff Bases of Isatin and 5-Fluoro- isatin in a Water Suspension Medium * A. A. Jarrahpour and D. Khalili Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran. * Author to whom correspondence should be addressed; Tel.: (+98) 711 228 4822; Fax: (+98) 711 228 0926; E-mail: aliasghar6683@ jarrah@susc.ac.ir Received: 27 April 2005; in revised form: 12 December 2005 / Accepted: 15 December 2005 / Pblished: 31 January 2006 Abstract: Condensation of aromatic primary bis-amines with isatin (1H-indole-2,3- dione) and 5-flouroisatin occurred cleanly and efficiently in a water suspension medium without using any organic solvent or acid catalyst. The corresponding bis-Schiff bases were obtained in good yields and were easily isolated by filtration. Their structures were confirmed by 1H-NMR, 13C-NMR, IR and mass spectra. Keywords: bis-Schiff bases; isatn, 5-fluoroisatin Introduction A big challenge facing academia and industry is the relationship of modern societies to the environment that requires reinventing the manufacture and use of materials. Synthetic methodologies nowadays should be designed to use and generate substances that possess little or no toxicity to human health and the environment. Schiff bases belong to a widely used group of organic intermediates important for production of specialty chemicals, e.g. pharmaceuticals, or rubber additives [1] and as amino protective groups in organic s