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synthesis of pla-b-peg multiblock copolymers for stealth drug carrier preparation合成pla-b-peg多次拉丝隐形药物载体制备的共聚物
Molecules 2005, 10, 98-104 molecules ISSN 1420-3049 Synthesis of PLA-b-PEG Multiblock Copolymers for Stealth Drug Carrier Preparation. Richard Quesnel and Patrice Hildgen* Faculté de Pharmacie, Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal (Québec), Canada, H3C 3J7 * Author to whom correspondence should be addressed; e-mail: Patrice.hildgen@umontreal.ca. Received: 17 May 2004 / Accepted: 2 July 2004 / Published: 31 January 2005 Abstract: An efficient method of preparing biodegradable and biocompatible multiblock copolymers from lactic acid and polyethylene glycol is proposed. Keywords: Copolymers, multiblock, lactic acid, polyethylene glycol. Introduction Biodegradable polymers are studied in an increasing number of medical applications. They are used as drug carriers and controlled release systems [1-5]. Some authors are interested in the possibilities that a copolymer consisting of polylactic acid (PLA) and polyethylene glycol (PEG) can offer, but synthesis of PLA/PEG copolymers via trans-esterification with PLA [6, 7] or ring opening of (D,L)-lactide [8-12] can only produce di-block or tri-block copolymers. A multiblock copolymer composed of PLA and PEG is of considerable interest as a drug carrier, since the PLA segments could provide rigidity [13], while the PEG portions confer stealth behavior [14]. Stealth microparticles have the ability to evade the immune system. They can then circulate after injection for longer periods of time without any takeover from the immune system, thus increasing their effective lifespan. PEG can also offer a certain degree of hydrophilicity to th
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