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synthesis of novel 3-hydrazino-3-oxo-n-(4-sulfamoylphenyl)-propanamide合成新型3-hydrazino-3-oxo-n -丙酰胺(4-sulfamoylphenyl).pdf

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synthesis of novel 3-hydrazino-3-oxo-n-(4-sulfamoylphenyl)-propanamide合成新型3-hydrazino-3-oxo-n -丙酰胺(4-sulfamoylphenyl)

Molbank 2009, M586 OPEN ACCESS molbank ISSN 1422-8599 /molbank Short Note Synthesis of novel 3-Hydrazino-3-oxo-N-(4-sulfamoylphenyl)- propanamide Arshi Naqvi 1,*, Mohd. Shahnawaaz 1, Arikatla V. Rao 1, Daya S. Seth 1 and Nawal K Sharma 2 1 Department of Chemistry, School of Chemical Sciences, St. Johns College, Agra-282002, India. 2 Department of Bioengineering, University of Pittsburgh, 260 Kappa Drive, RIDC Park, Pittsburgh, PA 15234 , USA. * Author to whom correspondence should be addressed; E-mail: arshi_84@ Received: 27 November 2008 / Accepted: 12 December 2008 / Published: 15 January 2009 Abstract: Novel 3-hydrazino-3-oxo-N-(4-sulfamoylphenyl)propanamide has been efficiently synthesized from DEM and hydrazine hydrate. The synthesized hydrazide was screened for anti-tubercular activity. Keywords: Synthesis, malonamic acid hydrazide, anti-tubercular activity. The full therapeutic possibilities of hydrazides were realized after the discovery of isonicotinic acid hydrazide (INH). Hydrazides and their derivatives have been described as useful synthons of various heterocyclic rings [1]. A large number of hydrazides and their derivatives are reported to possess a broad spectrum of biological activities [2-15]. Thus, these were found to be useful especially in the treatment of inflammatory and autoimmune diseases, osteoarthritis, respiratory diseases, tumors, cachexia, cardiovascular diseases, fever, hemorrhage and sepsis [11]. Hydrazides and derivatives exhibited antifungal [2], psychotropic [2], a