sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis b infection despite mutations conferring resistance to both drugs持续的病毒学和拉米夫定、阿德福伟生化反应组合在慢性乙型肝炎感染尽管突变两种药物产生抗性.pdfVIP

Comparative Hepatology BioMed Central Case Report Open Access Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs 1 2 1 1 Sylvie Larrat* , Marie-Noëlle Hilleret , Raphaele Germi , Julien Lupo , 1 2 1 Sandrine Nicod , Jean-Pierre Zarski , Jean-Marie Seigneurin and Patrice Morand1 Address: 1Laboratoire de Virologie moléculaire et structurale, CHU de Grenoble BP 217, 38043 Grenoble cedex 09, France and 2Département dhépatogastroentérologie, CHU de Grenoble BP 217, 38043 Grenoble cedex 09, France Email: Sylvie Larrat* - slarrat@chu-grenoble.fr; Marie-Noëlle Hilleret - mnhilleret@chu-grenoble.fr; Raphaele Germi - rgermi@ujf-grenoble.fr; Julien Lupo - lupo@embl.fr; Sandrine Nicod - snicod@chu-grenoble.fr; Jean-Pierre Zarski - jpzarski@chu-grenoble.fr; Jean- Marie Seigneurin - JmSeigneurin@chu-grenoble.fr; Patrice Morand - PMorand@chu-grenoble.fr * Corresponding author Published: 12 March 2008 Received: 22 August 2007 Accepted: 12 March 2008 Comparative Hepatology 2008, 7:3 doi:10.1186/1476-5926-7-3 This article is available from: /content/7/1/3 © 2008 Larrat et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and