synthesis and toxicity evaluation of some n4-aryl substituted 5-trifluoromethoxyisatin-3-thiosemicarbazones合成和毒性评价一些n4-aryl 5-trifluoromethoxyisatin-3-thiosemicarbazones代替.pdfVIP

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synthesis and toxicity evaluation of some n4-aryl substituted 5-trifluoromethoxyisatin-3-thiosemicarbazones合成和毒性评价一些n4-aryl 5-trifluoromethoxyisatin-3-thiosemicarbazones代替.pdf

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synthesis and toxicity evaluation of some n4-aryl substituted 5-trifluoromethoxyisatin-3-thiosemicarbazones合成和毒性评价一些n4-aryl 5-trifluoromethoxyisatin-3-thiosemicarbazones代替

Molecules 2011, 16, 6408-6421; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article 4 Synthesis and Toxicity Evaluation of Some N -Aryl Substituted 5-Trifluoromethoxyisatin-3-thiosemicarbazones Humayun Pervez 1,*, Naveeda Saira 1, Mohammad Saeed Iqbal 2, Muhammad Yaqub 1 and 3 Khalid Mohammed Khan 1 Department of Chemistry, Bahauddin Zakariya University, Multan-60800, Pakistan 2 Department of Chemistry, FC College, Lahore-54600, Pakistan 3 H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan * Author to whom correspondence should be addressed; E-Mail: pdhpervez@; Tel.: +92-61-9210083; Fax: +92-61-9210138. Received: 16 June 2011; in revised form: 13 July 2011 / Accepted: 22 July 2011 / Published: 29 July 2011 4 Abstract: A series of twenty one N -aryl substituted 5-trifluoromethoxyisatin-3- thiosemicarbazones 3a-3u was synthesized by the reaction of trifluoromethoxyisatin 1 with different arylthiosemicarbazides 2 in aqueous ethanol (50%), containing a few drops of acetic acid. Their structures were established on the basis of analytical (CHN) and spectral (IR, 1H-NMR, EIMS) data. All the synthesized compounds were evaluated for their toxicity potential by a brine shrimp