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Appl. Sci. 2012, 2, 13-23; doi:10.3390/app2010013 OPEN ACCESS applied sciences ISSN 2076-3417 /journal/applsci Article Surface Sampling of a Dry Aerosol Deposited Ricin Jason M. Edmonds 1,*, Patricia J. Collett 1, Rebecca L. Brown 1 and Kishna Mangaya 2 1 Edgewood Chemical Biological Center, United States Army, Department of Defense, 5183 Blackhawk Road, Aberdeen Proving Ground, MD 21010, USA; E-Mails: patricia.collett@ (P.J.C.); rebecca.l.brown160.civ@ (R.L.B.) 2 Science Applications International Corporation, 1710 SAIC Drive, McLean, VA 22102, USA; E-Mail: kishna.mangaya.ctr@ * Author to whom correspondence should be addressed; E-Mail: jason.edmonds1@; Tel.: +1-410-436-7348; Fax: +1-410-436-2165. Received: 8 December 2011; in revised form: 28 December 2011 / Accepted: 28 December 2011 / Published: 13 January 2012 Abstract: Sampling of small molecules from both porous and non-porous surfaces poses a significant challenge across biological agents. Particle sizes of toxins are smaller than living organisms and can be extremely toxic at low level concentrations. A small number of studies evaluating sampling efficiencies of commercial off the shelf (COTS) materials have been performed with toxins and proteins. However, they have been limited to non-ricin stimulants with drastically different physical properties than their native counterparts. We have identified a commercially available non-toxic recombinant ricin, complete with bo