synthesis and characterization of new thiazolidinones containing coumarin moieties and their antibacterial and antioxidant activities合成和表征的新thiazolidinones含有香豆素半个及其抗菌和抗氧化活性.pdfVIP

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synthesis and characterization of new thiazolidinones containing coumarin moieties and their antibacterial and antioxidant activities合成和表征的新thiazolidinones含有香豆素半个及其抗菌和抗氧化活性.pdf

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synthesis and characterization of new thiazolidinones containing coumarin moieties and their antibacterial and antioxidant activities合成和表征的新thiazolidinones含有香豆素半个及其抗菌和抗氧化活性

Molecules 2012, 17, 9321-9334; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Characterization of New Thiazolidinones Containing Coumarin Moieties and Their Antibacterial and Antioxidant Activities Naceur Hamdi 1,*, Abdullah Sulaiman Al-Ayed 1, Ridha Ben Said 1 and Alary Fabienne 2 1 College of Science and Arts at Ar-Rass, Qassim University, P.O. Box 53, Saudi Arabia 2 Laboratoire de chimie et physique quantiques, Université Paul Sabatier-Bât. 3R1b4, 118 route de Narbonne, 31062 Toulouse Cedex 09, France * Author to whom correspondence should be addressed; E-Mail: naceur.hamdi@isste.rnu.tn; Tel.: +966-505-142-736; Fax: +966-6333-9351. Received: 18 June 2012; in revised form: 21 July 2012 / Accepted: 24 July 2012 / Published: 3 August 2012 Abstract: New coumarin derivatives, namely (2-(4-methyl-2-oxo-2H-chromen-7-yloxy)- N-(4-oxo-2-phenylthiazolidin-3-yl)acetamide, N-(2-(3-methoxyphenyl)-4-oxothiazolidin- 3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide, 2-(4-methyl-2-oxo-2H-chromen- 7-yloxy)-N-(4-oxo-2-(2,3,4trimethoxyphenyl)thiazolidin-3-yl)acetamide and N-(2-(4- bromophenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide) were synthesized starting from 4-methyl-7-hydroxycoumarin. The structures of the obtained compounds were confirmed by analytical IR and NMR spectra to elucidate the different positions of protons and carbons and as well as theoretical studies (DFT/B3LYP). The new compounds wer