synthesis and characterization of multifunctional chitosan- mnfe2o4 nanoparticles for magnetic hyperthermia and drug delivery多功能的合成和表征壳聚糖- mnfe2o4纳米颗粒磁高热和药物输送.pdfVIP

Materials 2010, 3, 4051-4065; doi:10.3390/ma3074051  OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Synthesis and Characterization of Multifunctional Chitosan- MnFe O Nanoparticles for Magnetic Hyperthermia and Drug 2 4 Delivery Dong-Hyun Kim 1, David E. Nikles 2 and Christopher S. Brazel 1,* 1 Department of Chemical and Biological Engineering, Box 870203, The University of Alabama, Tuscaloosa, AL 35487-0203 USA; E-Mail: dhkim0405@ (D.-H.K.) 2 Department of Chemistry and Center for Materials for Information Technology, Box 870336, The University of Alabama, Tuscaloosa, AL 35487 USA; E-Mail: dnikles@ (D.N.) * Author to whom correspondence should be addressed; E-Mail: cbrazel@ (C.B.); Tel.: +1-205-348-9738; Fax: +1-205-348-7558. Received: 20 May 2010 / Accepted: 1 July 2010 / Published: 13 July 2010 Abstract: Multifunctional nanoparticles composed of MnFe O were encapsulated in 2 4 chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe O to be used as an efficient MRI contrast agent for cancer diagnosis. This paper 2 4 focuses on the synthesis and characterization of magnetic MnFe2O4 nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the Mn