synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones合成和抗肿瘤的评价6-aryl-substituted苯并[j]菲啶和苯并[g]pyrimido isoquinolinequinones(4、5度).pdfVIP

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synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones合成和抗肿瘤的评价6-aryl-substituted苯并[j]菲啶和苯并[g]pyrimido isoquinolinequinones(4、5度).pdf

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synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones合成和抗肿瘤的评价6-aryl-substituted苯并[j]菲啶和苯并[g]pyrimido isoquinolinequinones(4、5度)

Molecules 2012, 17, 11616-11629; doi:10.3390/molecules171011616 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j ]phenanthridine- and Benzo[g ]pyrimido[4,5-c]isoquinolinequinones Jennyfer Iribarra 1, David Vásquez 2,3, Cristina Theoduloz 4, Julio Benites 1,3, David Ríos 1,3 and Jaime A. Valderrama 3,5,* 1 Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile 2 Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380492, Chile 3 Instituto de EtnoFarmacología (IDE), Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile 4 Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile 5 Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 6094411, Chile * Author to whom correspondence should be addressed; E-Mail: jvalderr@uc.cl; Tel.: +56-02-354-4432; Fax: +56-02-354-4744. Received: 10 September 2012; in revised form: 23 September 2012 / Accepted: 25 September 2012 / Published: 28 September 2012 Abstract: A variety of novel 6-arylsubstituted benzo[j ]phenanthridine- and benzo[g]- pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl- aldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro against one normal cell line (MRC-5 lung fibroblasts) and three human cancer cell lines (AGS human gastric adenocarcinoma