有哪些信誉好的足球投注网站synthesis and antiviral bioactivities of α-aminophosphonates containing alkoxyethyl moieties的合成和抗病毒生物活性α-aminophosphonates包含alkoxyethyl半个.pdfVIP
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synthesis and antiviral bioactivities of α-aminophosphonates containing alkoxyethyl moieties的合成和抗病毒生物活性α-aminophosphonates包含alkoxyethyl半个
Molecules 2006, 11, 666-676 molecules ISSN 1420-3049 Full Paper Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties Yingshu Xu 1, 2 1 1, 1 1 1 1 , Kai Yan , Baoan Song *, Gangfang Xu , Song Yang , Wei Xue , Deyu Hu , Ping 1 1 1 1 Lu , Guiping Ouyang , Linhong Jin and Zhuo Chen 1 Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China; E-mails: xuyingshu1976@126.com, xuguangf04@163.com, yangsdqj@126.com, shouldww@163.com, fcc.dyhu@, luping217@, oygp710@163.com, fcc.lhjin@, gychenzhuo@ 2 Laboratory of Medicinal Chemistry, Zunyi, Medical College, 563003, Zunyi, P. R. China * Author to whom correspondence should be addressed; E-mail: songbaoan22@ Tel: (+86) 851 3620521, Fax: (+86) 851 3622211. Received: 9 August 2006; in revised form: 5 September 2006 / Accepted: 5 September 2006 / Published: 6 September 2006 Abstract: A simple, efficient, and general method has been developed for the synthesis of various α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-
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