synthesis and antifungal evaluation of 1-aryl-2-dimethyl-aminomethyl-2-propen-1-one hydrochlorides合成和抗真菌的评价1-aryl-2-dimethyl-aminomethyl-2-propen-1-one盐酸盐.pdfVIP

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synthesis and antifungal evaluation of 1-aryl-2-dimethyl-aminomethyl-2-propen-1-one hydrochlorides合成和抗真菌的评价1-aryl-2-dimethyl-aminomethyl-2-propen-1-one盐酸盐.pdf

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synthesis and antifungal evaluation of 1-aryl-2-dimethyl-aminomethyl-2-propen-1-one hydrochlorides合成和抗真菌的评价1-aryl-2-dimethyl-aminomethyl-2-propen-1-one盐酸盐

Molecules 2011, 16, 4660-4671; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antifungal Evaluation of 1-Aryl-2-dimethyl- aminomethyl-2-propen-1-one Hydrochlorides Ebru Mete 1,*, Halise Inci Gul 2, Sinan Bilginer 2, Oztekin Algul 3, Mehmet Emin Topaloglu 2, 4 1 Medine Gulluce and Cavit Kazaz 1 Department of Chemistry, Faculty of Sciences, Ataturk University, 25240, Erzurum, Turkey 2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University, 33169, Mersin, Turkey 4 Department of Biology, Faculty of Sciences, Ataturk University, 25240, Erzurum, Turkey * Author to whom correspondence should be addressed; E-Mail: ebru25@.tr; Tel.: +90-442-2314407; Fax: +90-442-2360962. Received: 15 March 2011; in revised form: 27 May 2011 / Accepted: 31 May 2011 / Published: 3 June 2011 Abstract: The development of resistance to current antifungal therapeutics drives the search for new effective agents. The fact that several acetophenone-derived Mannich bases had shown remarkable antifungal activities in our previous studies led us to design and synthesize some acetophenone-derived Mannich bases, 1-8 and 2-acetylthiophene-derived Mannich base 9, 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochloride, to evaluate their antifungal activities. The designed