supramolecular complex formation by β-cyclodextrin and ferrocenylnaphthalene diimide-intercalated double stranded dna and improved electrochemical gene detection超分子复合物形成β-cyclodextrin和ferrocenylnaphthalene diimide-intercalated双链dna和改善电化学基因检测.pdfVIP

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supramolecular complex formation by β-cyclodextrin and ferrocenylnaphthalene diimide-intercalated double stranded dna and improved electrochemical gene detection超分子复合物形成β-cyclodextrin和ferrocenylnaphthalene diimide-intercalated双链dna和改善电化学基因检测.pdf

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supramolecular complex formation by β-cyclodextrin and ferrocenylnaphthalene diimide-intercalated double stranded dna and improved electrochemical gene detection超分子复合物形成β-cyclodextrin和ferrocenylnaphthalene diimide-intercalated双链dna和改善电化学基因检测

Molecules 2005, 10, 693-707 molecules ISSN 1420-3049 Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection Shinobu Sato, Takahiko Nojima, Michinori Waki and Shigeori Takenaka* Department of Materials Science, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka, 804-8550, Japan. PhoneFax:+81-93-884-3322 * Author to whom correspondence should be addressed; e-mail shige@che.kyutech.ac.jp. Received: 16 November 2004 / Accepted: 29 December 2004 / Published: 14 July 2005 Abstract: Ferrocenylnaphthalene diimide 1 can bind to double stranded DNA (dsDNA) by the threading intercalation mode and the resulting complex was stabilized further by β- cyclodextrin (CD) by forming a supramolecular complex. These complex formation processes were studied by spectroscopic, viscometric, and electrochemical means in the absence or presence of β-CD. Quantitative analysis by quartz crystal microbalance (QCM) and electrochemical experiments strongly suggested a 2:1 binding stoichiometry for β-CD to 1 threading-intercalated to the dsDNA-immobilized electrode. Owing to this supramolecular complex formation, electrochemical DNA detection based on 1 was improved considerably. Keywords: Ferrocenylnaphthalene diimide, β-cyclodextrin (CD), DNA, electrochemical detection, supramolecular complex Introduction Exploitation of supramolecular complex formation provides a new tool in nanotechnolo