sublingual immunotherapy clinical indications in the wao-slit position paper舌下免疫治疗临床适应症wao-slit意见书.pdfVIP

INVITED REVIEWS Sublingual Immunotherapy: Clinical Indications in the WAO-SLIT Position Paper Giovanni Passalacqua, MD, Enrico Compalati, MD, and Giorgio Walter Canonica, MD injection route2,3 for both adults and children. Because of the Abstract: Sublingual immunotherapy (SLIT) is a matter of only 20 increasing utilization of SLIT in Europe and many other years. Nonetheless, in this short period of time more than 60 countries worldwide, it was felt that a document or position randomized double blind placebo-controlled trials have been pub- paper on its clinical use, safety aspect, and unmet needs was lished, in addition to postmarketing surveillance studies and meta- necessary. For this reason, the World Allergy Organization analyses. The wide diffusion of SLIT in clinical practice and the convened a meeting in Paris during January 2009 to prepare large availability of experimental data prompted the WAO to pub- and discuss a position paper. This was released as a draft lish a position paper on SLIT, to identify the indications, contrain- within June 2009 and subsequently endorsed by almost all the dications, and practical aspects of the t