submerged fermentation of the edible mushroom pleurotus ostreatus in a batch stirred tank bioreactor as a promising alternative for the effective production of bioactive metabolites深层发酵的可食用的蘑菇平菇在一批搅拌釜反应器作为一个有前途的替代方案的有效生物活性代谢产物的生产.pdfVIP

Molecules 2012, 17, 2714-2724; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Submerged Fermentation of the Edible Mushroom Pleurotus ostreatus in a Batch Stirred Tank Bioreactor as a Promising Alternative for the Effective Production of Bioactive Metabolites 1 2 1 1 Lefki-Maria Papaspyridi , Nektarios Aligiannis , Evangelos Topakas , Paul Christakopoulos , Alexandros-Leandros Skaltsounis 2 and Nikolas Fokialakis 2,* 1 BIOtechMASS Unit, Biotechnology Laboratory, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Street, Zografou Campus, GR-15700 Athens, Greece; E-Mails: leriapap@mail.ntua.gr (L.-M.P.); vtopakas@central.ntua.gr (E.T.); hristako@chemeng.ntua.gr (P.C.) 2 Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimioupolis, GR-15771 Athens, Greece; E-Mails: aligiannis@pharm.uoa.gr (N.A.); skaltsounis@pharm.uoa.gr (A.-L.S.) * Author to whom correspondence should be addressed; E-Mail: fokialakis@pharm.uoa.gr; Tel.: +30-210-7274-727; Fax: +30-210-7274-594. Received: 23 December 2011; in revised form: 20 February 2012 / Accepted: 22 February 2012 / Published: 6 March 2012 Abstract: The aim of this study was to investigate the potential of the submerged fermentation procedure in the production of bioactive metabolites of the common edible mushroom Pleurotus ostreatus. The