有哪些信誉好的足球投注网站steroidogenesis in the adrenal dysfunction of critical illness impact of etomidate类固醇生成肾上腺功能障碍的关键疾病依托咪酯的影响.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
steroidogenesis in the adrenal dysfunction of critical illness impact of etomidate类固醇生成肾上腺功能障碍的关键疾病依托咪酯的影响
Molenaar et al. Critical Care 2012, 16:R121 /content/16/4/R121 RESEARCH Open Access Steroidogenesis in the adrenal dysfunction of critical illness: impact of etomidate 1† 1† 1 2 1 Nienke Molenaar , Ronald M Bijkerk , Albertus Beishuizen , Christel M Hempen , Margriet FC de Jong , 2 2 1 1* Istvan Vermes , Gertjan van der Sluijs Veer , Armand RJ Girbes and AB Johan Groeneveld Abstract Introduction: This study was aimed at characterizing basal and adrenocorticotropic hormone (ACTH)-induced steroidogenesis in sepsis and nonsepsis patients with a suspicion of critical illness-related corticosteroid insufficiency (CIRCI), taking the use of etomidate-inhibiting 11b-hydroxylase into account. Method: This was a prospective study in a mixed surgical/medical intensive care unit (ICU) of a university hospital. The patients were 62 critically ill patients with a clinical suspicion of CIRCI. The patients underwent a 250- μg ACTH test (n = 67). ACTH, adrenal steroids, substrates, and precursors (modified tandem mass spectrometry) also were measured. Clinical characteristics including use of etomidate to facilitate intubation (n = 14 within 72 hours of ACTH testing) were recorded. Results: At the time of ACTH testing, patients had septic (n = 43) or nonseptic critical illness (n = 24). Baseline cortisol directly related to sepsis and endogenous ACTH, independent of etomidate use. Etomidate was associated with a lower baseline cortisol and cortisol/11b-deoxycortisol ratio as well as higher 11b-deoxycortisol, reflecting greater 11b-hydroxylase inhibition in nonsepsis tha
您可能关注的文档
- spag16, an axonemal central apparatus gene, encodes a male germ cell nuclear speckle protein that regulates spag16 mrna expressionspag16,axonemal中央装置基因,编码一个男性生殖细胞的核散斑蛋白调节spag16 mrna的表达.pdf
- sources of variation of the cattle secondary sex ratio变异来源的牛次要的性别比例.pdf
- sparse detector imaging sensor with two-class silhouette classification稀疏的探测器成像传感器与两轮廓分类.pdf
- sparse estimation for structural variability稀疏估计结构的变化.pdf
- sparse graphical gaussian modeling of the isoprenoid gene network in arabidopsis thaliana稀疏的图形高斯建模的类异戊二烯在拟南芥基因网络.pdf
- sparse representation of sounds in the unanesthetized auditory cortex病患稀疏表示声音的听觉皮层.pdf
- sonoelectrochemical synthesis of nanoparticlessonoelectrochemical纳米颗粒的合成.pdf
- sparsification of rna structure prediction including pseudoknotssparsification包括基因的rna结构预测.pdf
- spatial analysis of land cover determinants of malaria incidence in the ashanti region, ghana空间分析的土地覆盖的决定因素在阿善堤地区疟疾发病率,加纳.pdf
- spatial analysis of air pollution and childhood asthma in hamilton, canada comparing exposure methods in sensitive subgroups空间分析汉密尔顿市空气污染和儿童哮喘的加拿大比较曝光方法在敏感的子组.pdf
- stochastic modeling of empirical time series of childhood infectious diseases data before and after mass vaccination随机建模的经验时间序列儿童传染病大规模疫苗接种前后的数据.pdf
- stochastic e2f activation and reconciliation of phenomenological cell-cycle models现象学细胞循环模型的随机e2f激活与和解.pdf
- stochastic population dynamics of a montane ground-dwelling squirrel随机种群动态的山区陆生松鼠.pdf
- stochastic processes are key determinants of short-term evolution in influenza a virus随机过程是短期内甲型流感病毒进化的关键决定因素.pdf
- stochastic species turnover and stable coexistence in a species-rich, fire-prone plant community随机物种周转率稳定共存物种丰富,易燃植物群落.pdf
- stimulus motion propels traveling waves in binocular rivalry在双目竞争刺激运动推动旅游浪潮.pdf
- stoichiometric and catalytic synthesis of alkynylphosphines化学计量和alkynylphosphines催化合成.pdf
- stochasticity in protein levels drives colinearity of gene order in metabolic operons of escherichia coli特性转化在蛋白质水平驱动器同线性大肠杆菌的代谢操纵子基因秩序.pdf
- stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminalstomatin抑制pannexin-1-mediated与其羧基末端全细胞电流的相互作用.pdf
- stockpiling and comprehensive utilization of red mud research progress赤泥堆存及综合利用的研究进展.pdf
文档评论（0）