soluble guanylyl cyclase is reduced in airway smooth muscle cells from a murine model of allergic asthma可溶性guanylyl环化酶是降低气道平滑肌细胞的小鼠过敏性哮喘模型.pdfVIP

ORIGINAL ARTICLE Soluble Guanylyl Cyclase Is Reduced in Airway Smooth Muscle Cells From a Murine Model of Allergic Asthma Fabiola Placeres-Uray, PhD, Ramona Gonza´lez de Alfonzo, PhD, Itala Lippo de Becemberg, MD, PhD, and Marcelo J. Alfonzo, MD, PhD reactivity. These elements together are responsible for revers- Abstract: Airway remodeling plays an important role in the devel- ible obstruction of the airways and the clinical expression of opment of airway hyperresponsiveness in asthma. Muscarinic ago- asthma.1–3 nists such as carbamylcholine increased cyclic GMP (cGMP) levels This chronic inflammatory process leads to structural in bovine tracheal smooth muscle strips, via stimulation of NO- changes in the bronchial wall, involving hypertrophy and sensitive soluble guanylylcyclase (NO-sGC), which is an enzyme 2–5 hyperplasia of smooth muscle cells of airways (ASMCs) as highly expressed in the lungs. cGMP production, by activation of a described above. The role of ASMCs in airway remodeling is NO-sGC, may contribute to airway smooth muscle relaxation. To supported by increased muscle mass in the bronchial tree. In determine whether the bronchoconstrictio