soluble fas ligand inhibits angiogenesis in rheumatoid arthritis可溶性fas配体抑制血管生成在风湿性关节炎.pdfVIP

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soluble fas ligand inhibits angiogenesis in rheumatoid arthritis可溶性fas配体抑制血管生成在风湿性关节炎.pdf

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soluble fas ligand inhibits angiogenesis in rheumatoid arthritis可溶性fas配体抑制血管生成在风湿性关节炎

Available online /content/9/2/R42 Vol 9 No 2 Open Access Research article Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis 1 1 1 1 1 Wan-Uk Kim , Seung-Ki Kwok , Kyung-Hee Hong , Seung-Ah Yoo , Jin-Sun Kong , Jongseon Choe2 and Chul-Soo Cho1 1Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul 137-701, Korea 2Department of Microbiology and Immunology, Kangwon National University College of Medicine, Chunchon, Kangwon 200-701, Korea Corresponding author: Chul-Soo Cho, chocs@catholic.ac.kr Received: 10 Oct 2006 Revisions requested: 13 Nov 2006 Revisions received: 12 Mar 2007 Accepted: 26 Apr 2007 Published: 26 Apr 2007 Arthritis Research Therapy 2007, 9:R42 (doi:10.1186/ar2181) This article is online at: /content/9/2/R42 © 2007 Kim et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The characteristics of rheumatoid arthritis (RA) pathology the apoptosis of RA fibroblast-like synoviocytes (FLS) in vitro, include the infiltration of inflammatory leukocytes, the and thereby decreased VEGF165 production. In addition, sFasL proliferation of synovial cells, and the presence of extensive inhibited VEGF165-induced migration and chemotaxis of angiogenesis, referred to as rheumatoid pannus. Fas