an anti-hiv-1 v3 loop antibody fully protects cross-clade and elicits t-cell immunity in macaques mucosally challenged with an r5 clade c shiv一个anti-hiv-1 v3循环抗体完全保护cross-clade和抒发t细胞免疫的猕猴r5分支c shiv粘膜受到挑战.pdfVIP
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an anti-hiv-1 v3 loop antibody fully protects cross-clade and elicits t-cell immunity in macaques mucosally challenged with an r5 clade c shiv一个anti-hiv-1 v3循环抗体完全保护cross-clade和抒发t细胞免疫的猕猴r5分支c shiv粘膜受到挑战
An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-
Clade and Elicits T-Cell Immunity in Macaques Mucosally
Challenged with an R5 Clade C SHIV
Jennifer D. Watkins1,2., Nagadenahalli B. Siddappa1,2., Samir K. Lakhashe1,2, Michael Humbert1,2, Anton
1,2 1 1 1 1 3,4
Sholukh , Girish Hemashettar , Yin Ling Wong , John K. Yoon , Wendy Wang , Francis J. Novembre ,
3,5 3 3 6 6 6
Francois Villinger , Chris Ibegbu , Kalpana Patel , Davide Corti , Gloria Agatic , Fabrizia Vanzetta ,
6 7 8 8 1,2
Siro Bianchi , Jonathan L. Heeney , Federica Sallusto , Antonio Lanzavecchia , Ruth M. Ruprecht *
1 Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 2 Harvard Medical School, Boston, Massachusetts, United States of America, 3 Yerkes
National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, 4 Department of Microbiology and Immunology, Emory University,
Atlanta, Georgia, United States of America, 5 Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America, 6 Humabs
SAGL, Bellinzona, Switzerland, 7 Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, 8 Institute for Research in Biomedicine,
Bellinzona, Switzerland
Abstract
Neutralizing antibodies have been shown to protect mac
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