有哪些信誉好的足球投注网站a sensitive tg assay or rhtsh stimulated tg whats the best in the long-term follow-up of patients with differentiated thyroid carcinoma一个敏感的tg分析或rhtsh刺激tg的最佳分化型甲状腺癌患者的长期随访.pdfVIP
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a sensitive tg assay or rhtsh stimulated tg whats the best in the long-term follow-up of patients with differentiated thyroid carcinoma一个敏感的tg分析或rhtsh刺激tg的最佳分化型甲状腺癌患者的长期随访
A Sensitive Tg Assay or rhTSH Stimulated Tg: What’s the
Best in the Long-Term Follow-Up of Patients with
Differentiated Thyroid Carcinoma?
1 2 1 3 1 1
Adrienne C. M. Persoon , Pieter L. Jager , Wim J. Sluiter , John T. M. Plukker , Bruce H. R. Wolffenbuttel , Thera P. Links *
1 Department of Endocrinology, University Medical Centre Groningen, University of Groningen, The Netherlands, 2 Department of Nuclear Medicine,
University Medical Centre Groningen, University of Groningen, The Netherlands, 3 Department of Surgery, University Medical Centre Groningen,
University of Groningen, The Netherlands
Sensitivity of thyroglobulin (Tg) measurement in the follow-up of differentiated thyroid carcinoma (DTC) can be optimized by
using a sensitive Tg assay and rhTSH stimulation. We evaluated the diagnostic yield of a sensitive Tg assay and rhTSH
stimulated Tg in the detection of recurrences in the follow-up of DTC. Additionally the value of imaging techniques for the
localization of recurrences was evaluated. We included 121 disease free patients in long-term follow-up for DTC (median 10
years, range 1–34). Tg during thyroid hormone suppression therapy (Tg-on) and rhTSH stimulated Tg were measured with
a sensitive Tg assay. Patients with rhTSH stimulated Tg $1.0 ng/ml underwent imaging with neck ultrasound, FDG-PET and
post therapy 131I WBS. Sensitive Tg measurement resulted in 3 patients with Tg-on $1.0 ng/ml, recurrence could be localized
in 2 of them. RhTSH stimulation resulted in Tg $1.0 ng/ml in another 17 of 118 patients. Recurrence could be localized in only
1 additional patient (1 out of 118 patients). Recurrence was localized by neck ultrasound in 1 of 3, by FDG-PET in 2 of 3 and by
post therapy 131I WBS in 2 of 3 patients. In the detection of recurrences in DTC, rhTSH
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