a new approach for heparin standardization combination of scanning uv spectroscopy, nuclear magnetic resonance and principal component analysis肝素钠的新方法的标准化组合扫描紫外光谱、核磁共振和主成分分析.pdfVIP
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A New Approach for Heparin Standardization:
Combination of Scanning UV Spectroscopy, Nuclear
Magnetic Resonance and Principal Component Analysis
1 2 1 1 1
Marcelo A. Lima , Timothy R. Rudd , Eduardo H. C. de Farias , Lyvia F. Ebner , Tarsis F. Gesteira ,
4 1 ´ 1 ˜ 1 3
Lauro M. de Souza , Aline Mendes , Carolina R. Cordula , Joao R. M. Martins , Debra Hoppensteadt ,
3 4 2 1 1
Jawed Fareed , Guilherme L. Sassaki , Edwin A. Yates , Ivarne L. S. Tersariol , Helena B. Nader *
´ ˜ ˜
1 Departamento de Bioquımica, Disciplina de Biologia Molecular, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 2 School of Biological Sciences, University of
´
Liverpool, Liverpool, United Kingdom, 3 Department of Pathology, Loyola University Medical Center, Maywood, Illinois, United States of America, 4 Laboratorio de
´ ´ ´ ´
Quımica de Carboidratos, Departamento de Bioquımica e Biologia Molecular, Universidade Federal do Parana, Curitiba, Parana, Brazil
Abstract
The year 2007 was marked by widespread adverse clinical responses to heparin use, leading to a global recall of
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